Synthesis of Some Mannich and 2,5-Disubstituted 4-Thiazolidinone Compounds Derived from 4-amino Sulphamethaoxazole
Khalid A. Al-Badrany* Ayad S. Hamad** Ihmood K. Al-Juboori ***
*Sciences Food & Biotechnology Department, College of Agriculture.- University of Tikrit
** Chemistry Department, College of Education - University of Tikrit
*** Chemistry Department, College of Science - University of Tikrit
Received date: 31/5/2012 Accepted date: 6/10/2013
4-Chloro acetyl amino sulphamethaoxazole (A1) was synthesized by the reaction of amino sulphamethaoxazole with chloro acetyl chloride, Then refluxed with ammonium thiocyanate to obtain thiazoldine-4-one (A2) . (A2) was stirred with formaldehyde and various secondary amines to gain 5 novel compounds Mannich bases(A3-7).and 2,5-Disubstituted thiazolidine-4-one (A8-11) were synthesized by the reaction of substituted benzyldehyd with Compound (A2) . The structure of the synthesized compounds are confirmed by I.R, 1H-NMR & 13C-NMR spectra and Some chemical physical data.
Key Words: synthesis Mannich bases, 2,5-Disubstituted 4-thiazolidinones.
kirkuk university journal scientific studies
Publisher: Kirkuk University
Language: Arabic and English
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